The effect of intraoperative blood transfusion on postoperative deep vein thrombosis in patients with orthopedic trauma
10.3760/cma.j.cn115530-20210117-00028
- VernacularTitle:术中输血对创伤骨科患者术后深静脉血栓形成的影响研究
- Author:
Jianping SUN
1
;
Hanzhong XUE
;
Kun ZHANG
;
Qian WANG
;
Mingming HOU
;
Liang SUN
;
Binfei ZHANG
;
Zhong LI
Author Information
1. 西安交通大学医学院附属红会医院创伤骨科 710045
- Keywords:
Venous thrombosis;
Fractures, bone;
Perioperative care;
Blood transfusion;
Prognosis
- From:
Chinese Journal of Orthopaedic Trauma
2021;23(9):793-797
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of intraoperative blood transfusion on postoperative deep vein thrombosis in patients with orthopedic trauma.Methods:A retrospective analysis was conducted of the 502 patients who had been treated operatively at Department of Orthopaedics and Trauma, Xi＇an Honghui Hospital from January 2015 to September 2018. They were divided into 2 groups according to the use of intraoperative blood transfusion. In the observation group of 203 cases who had received intraoperative blood transfusion, there were 98 males and 105 females with an age of (61.0±20.7) years; in the control group of 299 cases who had not received intraoperative blood transfusion, there were 166 males and 133 females with an age of (57.7±19.0) years. Blood coagulation series such as D-dimer and fibrinogen were measured at admission, 1 day pre-operation, 1 day and 3 days postoperation. After operation, venous ultrasound examination of both lower limbs was performed to observe postoperative DVT in the patients. The 2 groups were compared in changes in coagulation series and occurrence of postoperative DVT.Results:There was no statistically significant difference in the preoperative general data between the 2 groups ( P>0.05), showing they were comparable. There was no significant difference between the observation group and the control group in the D-dimer level at admission or 1 day pre-operation ( P>0.05), but the D-dimer levels at 1 day and 3 days postoperation in the observation group [4.18 (2.35, 7.08) mg/L and (6.20±3.77) mg/L] were significantly higher than those in the control group [3.41 (1.91, 5.63) mg/L and (4.05±2.62) mg/L] ( P<0.05). There was no statistically significant difference in fibrinogen between the 2 groups at different time points ( P>0.05). The incidence of DVT in the observation group was 43.3% (88/203), significantly higher than that in the control group (32.8%, 98/299) ( P<0.05). Conclusion:As intraoperative blood transfusion can increase the level of D-dimer and thus the incidence of postoperative venous thrombosis in patients with orthopaedic trauma, we should pay more attention to the risk of postoperative DVT in patients receiving intraoperative blood transfusion.
