Research progress in application of low molecular weight heparin assisted by anti-X activity monitoring in the prevention of thrombosis after traumatic brain injury
10.3760/cma.j.cn501098-20210730-00411
- VernacularTitle:抗X活性浓度监测辅助低分子肝素预防血栓在创伤性脑损伤中应用的研究进展
- Author:
Renfu YAN
1
;
Sheng QIU
;
Zhongzhou SU
Author Information
1. 浙江省湖州市中心医院神经外科 313000
- Keywords:
Brain injuries;
Venous thromboembolism;
Heparin, Low-molecular-weight;
Anti- factor Xa
- From:
Chinese Journal of Trauma
2021;37(12):1141-1146
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of venous thromboembolism（VTE）in patients with traumatic brain injury（TBI）, especially in patients with severe TBI, is significantly increased due to disturbance of consciousness and limb movement. In the acute phase of VTE, low molecular weight heparin（LMWH）is the most commonly used safe and effective measure to prevent thrombosis. Due to the changes of injury condition of trauma patients, the deviation of clinicians' understanding of VTE and the medication habits of various medical institutions, there are significant differences in the initial time and dose of LMWH prevention. Insufficient or excessive dose of LMWH will lead to thrombus or bleeding complications. In recent years, administration of LMWH with anti-X activity monitoring has been paid more and more attention in patients with TBI, playing an important role in reducing the incidence of thrombosis. The authors review the research progress in the application of LMWH with anti-X activity monitoring in thrombus prevention in patients with TBI from the aspects of mechanism in LMWH use with anti-X activity monitoring, LWMH medication time window and anti-X activity monitoring, LWMH dose adjustment and anti-X activity monitoring, in order to provide references for clinical treatment.
