Research progress in molecular coupling mechanism of osteogenic differentiation and angiogenesis in traumatic bone defects
10.3760/cma.j.cn501098-20210129-00083
- VernacularTitle:成骨分化与血管生成中分子耦联机制在创伤性骨缺损中的研究进展
- Author:
Yuwan LI
1
;
Tong WU
;
Ziming LIU
;
Wenqiang YAN
;
Jun ZHANG
;
Miaoyuan LIN
;
Yaping TANG
;
Jianquan WANG
;
Ning HU
;
Yingfang AO
Author Information
1. 北京大学第三医院运动医学科，北京大学运动医学研究所，运动医学关节伤病北京市重点实验室 100191
- Keywords:
Osteogenesis;
Vascular remodeling;
Signal transduction;
Bone transplantation
- From:
Chinese Journal of Trauma
2021;37(10):947-954
- CountryChina
- Language:Chinese
-
Abstract:
Management of bone defects caused by fractures，bone tumors or infections is clinically difficult as well as a hot topic in current studies. With further researches over bone defects，the construction of tissue-engineered bone has played a great role in the treatment of bone defects. Blood vessels not only provide the necessary nutritional mineral salts，growth factors，hormones for bone formation，also are able to mediate the interaction among osteoblasts and osteoclasts，osteocytes，bone autonomic nerve and endothelial cells，since bone formation exist spatially and temporally connection with angiogenesis. Therefore，the authors make a systematic literature review on the research progress of the coupling mechanism of angiogenesis and osteogenic differentiation，blood vessels and related signal pathways on osteogenic differentiation and angiogenesis-related molecules in osteogenic differentiation during the process of traumatic bone defects，so as to provide new ideas for the treatment of bone defects.
