Research progress in function and related mechanism of gut-brain axis in traumatic brain injury
10.3760/cma.j.cn501098-20210428-00274
- VernacularTitle:脑肠轴在创伤性脑损伤中的作用及机制研究进展
- Author:
Chunan ZHAO
1
;
Jingyu ZHANG
;
Shuangshuang DAI
;
Yangwuyue LIU
Author Information
1. 陆军军医大学基础医学院生物化学与分子生物学教研室，重庆 400038
- Keywords:
Brain injuries;
Pathologic processes;
Gut-brain axis
- From:
Chinese Journal of Trauma
2021;37(9):841-847
- CountryChina
- Language:Chinese
-
Abstract:
Traumatic brain injury（TBI）in combination with its sequelae is currently a public health problem that seriously endangers human health. Accumulating studies have deeply investigated the pathological processes of TBI to find possible therapeutic targets. In recent years，the relationship between TBI pathogenesis and gut-brain axis changes in aspects of microflora，metabolites，inflammatory factors and neurohumoral changes has drawn widespread attention，which not only provides a better understanding how TBI affects gut-brain axis，but also provides new therapeutic targets in improving cure rate and recovery level after TBI. However，due to the existence of complicated gut-brain axis self-regulation as well as the individual differences of TBI patients，the recognition and transformation for the latest experimental research are largely limited. In this review，the authors summarize how TBI event influences gut-brain axis balance，as well as how gut-brain axis regulates TBI pathogenesis mutually，so as to provide a better understanding of the interaction between gut-brain axis and TBI.
