Research progress in role and mechanism of damage-associated molecular patterns in lung injury after acute spinal cord injury

VernacularTitle:损伤相关分子模式在急性脊髓损伤后肺损伤中的作用机制研究进展
Author: Qing CHEN ¹ ; Dong XIE ; Qiuju YAO ; Lili YANG
Author Information

1. 海军军医大学第二附属医院（上海长征医院）脊柱外科　200003
Keywords: Spinal cord injuries; Lung injuries; Damage-associated molecular patterns
From: Chinese Journal of Trauma 2021;37(8):756-760
CountryChina
Language:Chinese
Abstract: Acute spinal cord injury（ASCI），commonly seen in spinal surgery，is usually caused by mechanical injury to the spine. ASCI can lead to secondary lung injury and even acute respiratory distress syndrome（ARDS），seriously endangering the life safety of patients. Damage-associated molecular pattern（DAMP）is a sort of endogenous substances released after injury，including intracellular proteins，extracellular matrix，secretory factors and nucleic acid-related products. DAMP released after ASCI activates downstream signaling pathways and participates in lung injuries. DAMP-related studies have revealed molecular mechanism of lung injury after ASCI，and explored the possible therapeutic targets of lung injury. In this study，the authors review the mechanism of action of DAMP in lung injury after ASCI and the role of different kinds of DAMP in lung injury，so as to provide new ideas for clinical treatment of lung injury after ASCI.