Research progress in molecular mechanism of bone homeostasis imbalance due to bone infection
10.3760/cma.j.cn501098-20210112-00031
- VernacularTitle:骨感染导致骨稳态失衡的分子机制研究进展
- Author:
Shidan LI
1
;
Shaochuan WANG
;
Youbin LI
;
Xiaoyu XIE
;
Wei XING
;
Jun FEI
Author Information
1. 陆军军医大学大坪医院骨科，重庆 400042
- Keywords:
Osteomyelitis;
Bone remodeling;
Osteonecrosis;
Bone regeneration
- From:
Chinese Journal of Trauma
2021;37(7):666-672
- CountryChina
- Language:Chinese
-
Abstract:
Bone infection is an osteal disorder with bone damage resulting from infection of bone marrow，cortex，periosteum and surrounding tissues，characterized by a high incidence and severe symptoms. The treatment is often complicated and prolonged. Regardless of the method used，the goal is to reduce bone defect caused by infection，control infection，rebuild impaired tissues，and promote bone healing，so as to restore bone homeostasis. Starting from bone homeostasis，the authors review the research progress in the commonly used drugs and molecular mechanisms that affect bone formation-related pathways caused by bone infection，activate bone resorption-related mechanisms，and regulate bone homeostasis，in order to provide a theoretical basis for reducing bone defect caused by bone infection and promoting bone healing.
