Pathological mechanism and research progress of competitive sport inducing chronic traumatic encephalopathy

VernacularTitle:对抗性运动诱发慢性创伤性脑病的病理机制及其研究进展
Author: Yujing LI ¹ ; Junhan CHEN ; Kaiyu CAI ; Weicheng CHEN ; Wenqi LYU ; Xiangrong CHEN
Author Information

1. 福建医科大学附属第二医院神经外科，第二临床医学院，泉州　362000
Keywords: Athletic injuries; Craniocerebral trauma; Chronic traumatic encephalopathy
From: Chinese Journal of Trauma 2021;37(4):359-365
CountryChina
Language:Chinese
Abstract: The competitive sports are beneficial to cardiovascular system and brain health. However, physical exercise is accompanied with risks. Severe trauma is possible in competitive sports that may impact on the head and body. In recent years, more interests are aroused in sports-related traumatic brain injury(TBI), especially the mild TBI(mTBI). Repetitive mTBI can cause persistent cognitive, behavioral and mental problems, leading to chronic traumatic encephalopathy(CTE) and eventually resulting in neurodegeneration. In this study, the authors summarize the pathological characteristics and mechanism of CTE induced by mTBI due to competitive exercise so as to reveal the pathogenesis of CTE and provide valuable information for early diagnosis, development of disease biomarkers and explore effective therapeutic targets.