Research progress in immunoregulation mechanism of bone trauma microenvironment

VernacularTitle:骨创伤微环境免疫调控机制的研究进展
Author: Mengke FAN ¹ ; Ling WANG ; Lili QI ; Wei CHEN ; Yingze ZHANG
Author Information

1. 河北医科大学第三医院创伤急救中心，河北省骨科研究所，国家卫生健康委骨科智能器材实验室，石家庄　050051
Keywords: Fractures, bone; Immunomodulation; Inflammation; Trauma, bone
From: Chinese Journal of Trauma 2021;37(2):176-181
CountryChina
Language:Chinese
Abstract: Trauma induces immune cells to infiltrate the fracture site, and regulates the removal of local dead bone and remodeling of new bone by secreting a variety of cytokines and inflammatory mediators. With the development of trauma immunology, the role of the immune system in the process of bone wound healing has been deeply studied in recent years. When fracture occurs, the non-specific and specific immune cells are successively attracted into the fracture site, participating in bone repair. If there was a disorder in the bone trauma microenvironment, the coordination between osteoblasts and osteoclasts will be disordered, leading to delayed or nonunion of fractures. Therefore, it is very important to systematically explore the communication between immune cells and immune cells or osteoblasts/osteoclasts in bone trauma microenvironment. The authors review the immune regulation mechanism in the process of bone clearance and repair after bone trauma, and provide a rationale for the future immunotherapy of bone trauma.