Research progress in mechanism of mesenchymal stem cells-derived exosomes treating spinal cord injury

VernacularTitle:间充质干细胞外泌体治疗脊髓损伤作用机制的研究进展
Author: Wu CHEN ¹ ; Changgong LAN ; Hongcheng LUO
Author Information

1. 右江民族医学院研究生学院，百色　533000
Keywords: Spinal cord injuries; Exosomes; Mesenchymal stem cells
From: Chinese Journal of Trauma 2021;37(2):171-175
CountryChina
Language:Chinese
Abstract: Secondary injury and the glial scar after spinal cord injury can adversely affect nerve regeneration in the microenvironment, leading to treatment difficulties. Mesenchymal stem cells (MSCs) have multi-differentiation, self-renewal ability, participation in immune regulation and other functions and can be used to treat spinal cord injury, but they are not easy to pass the blood spine barrier and have high tumorigenicity and other disadvantages. MSCs-derived exosomes are nanometer exosomes secreted by MSCs, which contain many active substances. These exosomes have a strong neurorepair effect in spinal cord injury research, and have advantages of easy penetration, stability and low tumorigenicity, etc. These exosomes make up for the disadvantages of MSCs treatment, and are expected to replace MSCs in treatment of spinal cord injury. The authors review the biological characteristics of MSCs-derived exosomes and its mechanism in the treatment of spinal cord injury, so as to provide references for the treatment of spinal cord injury.