Analysis of drug resistance in patients with acquired immunodeficiency syndrome who failed antiviral therapy
10.3760/cma.j.cn311365-20200925-00797
- VernacularTitle:艾滋病抗病毒治疗失败患者的耐药情况分析
- Author:
Zhaoyun CHEN
1
;
Yan SUN
;
Chaofeng LI
;
Chunli LIU
;
Xuan YANG
;
Xue ZHANG
;
Yuanyuan CHEN
;
Yan CAI
;
Kun CAO
;
Qingxia ZHAO
Author Information
1. 郑州市第六人民医院感染科 450015
- Keywords:
Acquired immunodeficiency syndrome;
Drug resistance;
Antiretroviral treatment
- From:
Chinese Journal of Infectious Diseases
2021;39(8):480-484
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the drug resistance of patients with acquired immunodeficiency syndrome (AIDS) who failed antiviral therapy.Methods:A total of 156 AIDS patients with antiviral therapy failure at the Sixth People′s Hospital of Zhengzhou from October 2017 to December 2018 were selected. The human immunodeficiency virus (HIV)-1 ViroSeq? genotyping method was used for the detection of HIV resistance, and Stanford University HIV drug resistance database (http: ∥hivdb.stanford.edu/) was used for testing results comparison.Results:Among the 156 AIDS patients with antiviral therapy failure, 122(78.21%) developed drug resistance. One hundred and six (67.95%) cases were multi-resistant to nucleoside reverse transcriptase inhibitor (NRTI), among which, 104 (66.67%) were resistant to lamivudine, emtricitabine and abacavir. One hundred and eighteen (75.64%) were resistant to non-nucleoside reverse transcriptase inhibitor (NNRTI), and 118 (75.64%) were multi-resistant to efavirenz and nevirapine. And seven (4.49%) were resistant to protease inhibitor (PI). There were 16 resistant sites for NRTI, with 87 (71.31%) most frequent M184V/I mutations. There were 13 resistant sites for NNRTI, with 49 (40.16%) K103N/R mutations. There were 11 resistant sites for PI, with 49 (40.16%) A71V/T mutations. The antiviral drugs lamivudine and emtricitabine were moderately and highly resistant in 102 (83.61%) cases, efavirenz and nevirapine were moderately and highly resistant in 117 (95.90%) cases. Once drug resistance developed, these drugs were likely to be moderate or high resistance. There were 29 (23.77%), 48 (39.34%), and five (4.10%) cases were resistant to zidovudine, tenofovir and lopinavir/ritonavir, respectively. The resistance barrier of these drugs was relatively high.Conclusion:The incidence of drug resistance in patients with AIDS treatment failure is high, and multi-drug resistance is serious with various sites of drug resistance.
