Advances in the treatment of ovarian cancer with BRCA gene mutation
10.3760/cma.j.cn101721-20210406-00020
- VernacularTitle:BRCA基因突变卵巢癌的治疗进展
- Author:
Yadi ZHANG
1
;
Yanli ZHOU
;
Huamei LI
;
Yanli FENG
Author Information
1. 济宁医学院临床医学院 272000
- Keywords:
Ovarian cancer;
Breast cancer susceptibility gene;
Mutation;
Treatment
- From:
Clinical Medicine of China
2021;37(5):470-473
- CountryChina
- Language:Chinese
-
Abstract:
Ovarian cancer is the most fatal malignant tumor in female reproductive system tumors.In most women, it is diagnosed in a late stage, which largely leads to the poor prognosis of ovarian cancer.Breast cancer susceptibility gene (BRCA) is an important DNA homologous repair gene, which plays a major role in the normal cellular DNA repair mechanism.Its mutation will lead to homologous recombination defects, which will affect the stability of the genome and lead to occurrence of tumors.In recent years, BRCA genetic testing has become a key step in the risk assessment, prognosis, treatment and prevention of ovarian cancer.
