Double-edged effects of mitochondrial stress on cognitive function
10.3760/cma.j.cn431274-20200916-01298
- VernacularTitle:线粒体胁迫对认知功能的双刃影响
- Author:
Luyang FENG
1
;
Haiyun WANG
Author Information
1. 天津医科大学三中心临床学院，天津市第三中心医院麻醉科，天津市重症疾病体外生命支持重点实验室，天津市人工细胞工程技术研究中心，天津市肝胆研究所 300170
- Keywords:
Alzheimer disease;
Mitochondrial stress;
Cognition
- From:
Journal of Chinese Physician
2021;23(10):1597-1600
- CountryChina
- Language:Chinese
-
Abstract:
As the populations are aging, concerns about cognitive decline are becoming a common topic in medical consultations. The occurrence of postoperative cognitive change involves many factors such as their own situation and perioperative period. Alzheimer′s disease (AD) is the main concern about postoperative cognitive change. For years it was widely believed that cognitive dysfunction caused by anesthesia, some studies suggest that anesthetics may cause mitochondrial damage, while most studies suggest that mitochondrial dysfunction may affect AD. But it is rarely noticed, that cells can maintain the stability following mitochondrial stress by a series of integrated stress responses (ISR) and alleviate mitochondrial stress in progeny. We reviewed the research progress of mitochondrial stress in AD.
