Progressive symmetric erythematous keratosis with symptoms: a case report and literature analysis
10.3760/cma.j.cn431274-20200722-01019
- VernacularTitle:进行性对称性红斑角化症伴发症状病例报道并文献分析
- Author:
Yan DUAN
1
;
Yue HE
;
Ruiya LI
;
Jie WANG
;
Surui A
;
Fangfang LIU
;
Linye LI
;
Qian WANG
Author Information
1. 内蒙古自治区人民医院皮肤科，呼和浩特 010010
- Keywords:
Progressive symmetric erythema keratosis;
Keratoderma, palmoplantar;
Erythrokeratodermia variabilis
- From:
Journal of Chinese Physician
2021;23(9):1316-1320
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the associated symptoms of progressive symmetrical erythema keratosis (PSEK) and the related literature was reviewed.Methods:Two Mongolian PSEK families in the dermatology department of the People′s Hospital of Inner Mongolia Autonomous Region from 2016 to 2017 were collected, and 40 complete PSEK families and 156 sporadic cases at home and abroad published since 1980 to 2020 were searched by using the database to analyze the concomitant symptoms of PSEK.Results:A total of 40 complete PSEK families were included, including 714 cases. The incidence of PSEK was 57.38% in foreign countries and 37.42% in China; The most common concomitant symptoms abroad were palmoplantar keratosis (PPK), followed by nail changes, neurological symptoms, dysplasia, combined with variable erythema keratosis (EKV), and the concomitant symptoms were more serious; The most common concomitant symptoms in China were nail changes, followed by PPK, damp hyperhidrosis, pruritus, pain and some skin diseases, and the concurrent symptoms were mild.Conclusions:PSEK has many associated symptoms and the molecular genetic mechanism is still unclear. It is necessary to conduct a more comprehensive and in-depth study and understanding of the disease through the development of sequencing technology and the expansion of clinical cases.
