Research and development of correlation between myeloperoxidaseand colorectal cancer
10.3760/cma.j.cn431274-20200523-00655
- VernacularTitle:髓过氧化物酶与结直肠癌相关性的研究进展
- Author:
Haiqing LIANG
1
;
Yiran LI
;
Shuyan ZHANG
;
Liqun CAO
Author Information
1. 山东省德州市人民医院内二科 253014
- Keywords:
Colorectal neoplasms;
Myeloperoxidase;
Polymorphism, single nucleotide
- From:
Journal of Chinese Physician
2021;23(6):958-960,f3
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is one of the most common malignant tumors. Myeloperoxidase (MPO), as an oxidase in neutrophils lysosomes, plays an important role in activating carcinogenic gene intermediates and enhancing exogenous carcinogenesis. It can stimulate oxidative stress reaction in vivo by producing hypochlorite, reactive oxygen species and other oxidants, and induce gene instability factors such as DNA damage, mutation, mismatch repair and so on, which leads to the occurrence and development of colorectal cancer. MPO single nucleotide polymorphism (SNP) is related to the genetic susceptibility of cancer. Mpors 2333227-463G>A can reduce the risk of colorectal cancer. Therefore, the research on MPO, MPO-463G>A will provide new ideas and strong evidence for early detection, prevention, disease assessment and targeted treatment of colorectal cancer.
