Study on potential mechanism of hyperoside on improving ischemia/reperfusion injury based on network pharmacology
10.3867/j.issn.1000-3002.2021.10.088
- Author:
Jia-Jun LU
1
;
Chen-Chen JIANG
;
Lei SHI
;
Di CAO
;
Jun HAN
Author Information
1. Department of Pharmacology,Drug Research and Development Center,School of pharmacy,Wannan Medical College,Wuhu 241002,China
- Keywords:
hyperoside;
ischemia/reperfusion injury;
network pharmacology
- From:
Chinese Journal of Pharmacology and Toxicology
2021;35(10):769-769
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To predict the potential targets of hyperoside (Hyp) on improving ischemia/reperfusion injury by network pharmacology, and explore its possible mechanism combined with related literature. METHODS The action targets of Hyp and ischemia/reperfusion injury were obtained by TCMSP, Swiss Target Prediction, Pharm Mapper, Simi?larity ensemble approach, Online Mendelian Inheritance in Man, DisGENT and database. The common targets of drugs and diseases were screened by Omishare and STRING database respectively, and the protein-protein interaction (PPI) network map was constructed. Then the interaction network between Hyp and disease targets was constructed by Cyto?scape software and topological cross-linking analysis was carried out. Then the interaction network between Hyp and disease targets was constructed and cross-linked analysis was carried out by using Cytoscape software. The gene ontol?ogy (GO) of the core target was analyzed by David database, and then the related pathways of the core target were enriched by KEGG database. RESULTS A total of 54 GO enrichment processes were obtained by GO enrichment anal?ysis of 44 common genes, including 38 biological processes (BP), 15 cell composition (CC) processes, and 1 molecular functional (MF) process. 43 items were obtained by signal pathway enrichment analysis in KEGG database. CONCLU?SION It is suggested that the mechanism of Hyp may be related to PI3K-Akt, RAP1, RAS, VEGF and other signal trans?duction pathways. The above results laid a theoretical foundation for the study of the mechanism and clinical application of the treatment of ischemia/reperfusion injury.
