Pulsatilla chinensis:phytochemistry, pharmacology and new drug development
10.3867/j.issn.1000-3002.2021.10.085
- Author:
Mao-Lun LIU
1
;
Qiang SUN
;
Sha ZENG
;
Li CHEN
;
Hui ZHAO
;
Han YANG
;
Shan REN
;
Tian-Qi MING
;
Jin-Jian LU
;
Hai-Bo XU
Author Information
1. State Key Laboratory of Southwestern Chinese Medicine Resources,Department of Pharmacology,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China
- Keywords:
Pulsatilla chinensis;
phytochemistry;
pharmacology
- From:
Chinese Journal of Pharmacology and Toxicology
2021;35(10):767-767
- CountryChina
- Language:Chinese
-
Abstract:
Pulsatilla chinensis is a widely used traditional Chinese herb, which contains 56 types of chemical constit?uents, mainly including triterpenoid saponins, organic acids, coumarins and lignans. The largest portion of the ingredi?ents in Pulsatilla chinensis is the family of triterpenoid saponins, in which anemoside B4 is the major effective compound and indexing component. The main components of Pulsatilla chinensis can metabolize into a vast array of active prod?ucts in vivo, which play vital roles in its biological activity. Mounting evidence reveals that Pulsatilla chinensis exerts a wide range of therapeutic activities, such as anti-cancer, immunoregulation, anti-inflammation and anti-schistosome, with fewer adverse reactions, via various signaling pathways and multiple targets. It was documented that the active ingre?dient of Pulsatilla chinensis can lessen the drug resistance and synergize the effects of other natural products includ?ing paclitaxel, as well as ameliorate the clinical efficacy of chemical drugs, such as adriamycin. However, Pulsatilla chi?nensis was also reported to be possibly the main cause of hemolysis and chronic liver injury. The efforts should be made to deeply investigate the pharmacological actions and underlying mechanisms of Pulsatilla chinensis, with a focus on the anti-cancer efficacy, and develop new drugs based on the components of Pulsatilla chinensis for future utilization in the clinical setting.
