Clinical Significance of Component Allergens in Fagales Pollen-Sensitized Peanut Allergy in Korea.
10.4168/aair.2016.8.6.505
- Author:
Kyung Hee PARK
1
;
Young Woong SON
;
Sang Chul LEE
;
Kyunguk JEONG
;
Da Woon SIM
;
Hye Jung PARK
;
Sooyoung LEE
;
Jae Hyun LEE
;
Jung Won PARK
Author Information
1. Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. parkjw@yuhs.ac
- Publication Type:Original Article
- Keywords:
Allergens;
IgE;
peanut hypersensitivity;
pollen;
trees
- MeSH:
Allergens*;
Anaphylaxis;
Arachis*;
Betula;
Food Hypersensitivity;
Humans;
Hypersensitivity;
Immunoglobulin E;
Korea*;
Peanut Hypersensitivity*;
Pollen;
Rhinitis, Allergic, Seasonal;
Trees
- From:Allergy, Asthma & Immunology Research
2016;8(6):505-511
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Clinical features of peanut allergy can range from localized to systemic reactions. Because peanut and birch pollen have cross-reactivity, peanut can lead to localized allergic reaction in Fagales pollen-sensitized oral allergy syndrome (OAS) patients without peanut sensitization per se. The purpose of this study was to discriminate true peanut food allergy from cross-reactive hypersensitivity in birch-sensitized peanut allergy. METHODS: Birch-sensitized (n=81) and peanut anaphylaxis patients (n=12) were enrolled. Peanut-related allergic reactions and sensitization profiles were examined. Specific IgE to Fagales tree pollens (birch, oak), peanut, and their component allergens (Bet v 1, Bet v 2, Ara h 1, Ara h 2, Ara h 3, Ara h 8, and Ara h 9) were evaluated. Based on these specific IgEs and clinical features, the patients were classified into 4 groups: group 1 (Fagales pollen allergy without OAS), group 2 (Fagales pollen allergy with OAS), group 3 (OAS with peanut anaphylaxis), and group 4 (peanut anaphylaxis). RESULTS: After peanut consumption, one-third of OAS patients experienced oral symptoms not associated with peanut sensitization. Ara h 1 or Ara h 2 was positive in peanut anaphylaxis patients, whereas Ara h 8 was positive in OAS patients. There were 4 patients with both peanut anaphylaxis and OAS (group 3). Both Ara h 2 and Ara h 8 were positive in these patients. Foods associated with OAS in Korea showed unique patterns compared to Westernized countries. CONCLUSIONS: Ara h 2 and Ara h 8 may be important component allergens for discriminating peanut allergy.
