Chaetocin:a review of its anticancer potential and mechanisms
10.3867/j.issn.1000-3002.2021.10.019
- Author:
Hang-Yu JIANG
1
,
2
;
Yu-Qi LI
;
Xiao-Cong XIANG
;
Zhi-Li TANG
;
Kang LIU
;
Qiang SU
;
Xiao-Fen ZHANG
;
Lin LI
Author Information
1. Department of Pharmacy,The Second Clinical Medical College of North Sichuan Medical College,Nanchong 637000,China
2. School of Pharmacy,North Sichuan Medical College,Nanchong 637100,China
- Keywords:
chaetocin;
antitumor;
apoptosis;
signalling pathway
- From:
Chinese Journal of Pharmacology and Toxicology
2021;35(10):731-731
- CountryChina
- Language:Chinese
-
Abstract:
Chaetocin is a natural metabolite product with various biological activities and pharmacological functions isolated from Chaetomium species fungi belonging to the thiodiketopyrazines. Numerous studies have demonstrated a wide range of antitumor activities of chaetocin in vitro and in vivo. Several studies have demonstrated that chaetocin sup?presses the growth and proliferation of various tumour cells by regulating multiple signalling pathways related to tumour initiation and progression, inducing cancer cell apoptosis (intrinsic and extrinsic), enhancing autophagy, inducing cell cycle arrest, as well as inhibiting tumour angiogenesis, invasion and migration. The antitumor effects and molecular mechanisms of chaetocin are reviewed and analysed in this paper, and the prospective applications of chaetocin in cancer prevention and therapy are also discussed. Our review provides the theoretical basis for exploiting the clinical applica?tion of chaetocin in cancer treatment.
