Plasma Levels of Matrix Metalloproteinase-9 in Children With Chronic Spontaneous Urticaria.
10.4168/aair.2016.8.6.522
- Author:
Fatih DILEK
1
;
Deniz OZCEKER
;
Emin OZKAYA
;
Zeynep TAMAY
;
Mebrure YAZICI
;
Siddika KESGIN
;
Abdurrahim KOCYIGIT
;
Nermin GULER
Author Information
1. Department of Pediatric Allergy and Immunology, Bezmialem Vakif University Medical Faculty, Istanbul, Turkey. drfatihdilek@yahoo.com
- Publication Type:Original Article
- Keywords:
Chronic spontaneous urticaria;
children;
disease severity;
MMP-9
- MeSH:
Adult;
Child*;
Enzyme-Linked Immunosorbent Assay;
Humans;
Matrix Metalloproteinase 9*;
Plasma*;
Skin Tests;
Urticaria*
- From:Allergy, Asthma & Immunology Research
2016;8(6):522-526
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Chronic spontaneous urticaria (CSU) is a disease that is primarily seen in adults and is comparatively rare in children. Consequently, only a few studies have focused on the pathogenesis of the disease in children. This study investigated the possible role of metalloproteinase-9 (MMP-9) in the pathogenesis of CSU in children. METHODS: The study group was composed of 54 children with CSU; 34 healthy children comprised the control group. The demographic and clinical features of the study group were extensively evaluated, and laboratory assessments were also performed. An enzyme-linked immunosorbent assay was used to evaluate levels of plasma MMP-9. Disease activity was quantified using the urticaria activity score (UAS). RESULTS: The median value of plasma MMP-9 was 108.9 ng/mL (interquartile range, 93.3-124.1) in the CSU group and 87.8 ng/mL (69.4-103.0) in the control group. The difference between the 2 groups was statistically significant (P<0.001). Also, MMP-9 levels showed a significant positive correlation with UAS (rho=0.57, P<0.001). Twenty-six percent of patients had positive autologous serum skin test (ASST) results. Neither UAS nor plasma MMP-9 levels were significantly different between ASST-positive and -negative patients (P>0.05). CONCLUSIONS: Plasma MMP-9 levels were elevated in children with CSU and were positively correlated with disease activity. MMP-9 may be both a good biomarker of disease activity and a potential therapeutic target in CSU.
