The Basophil Activation Test Is Safe and Useful for Confirming Drug-Induced Anaphylaxis.
10.4168/aair.2016.8.6.541
- Author:
Suk Yeon KIM
1
;
Joo Hee KIM
;
Young Sook JANG
;
Jeong Hee CHOI
;
Sunghoon PARK
;
Yong Il HWANG
;
Seung Hun JANG
;
Ki Suck JUNG
Author Information
1. Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea. luxjhee@gmail.com
- Publication Type:Brief Communication
- Keywords:
Anaphylaxis;
basophil;
drug allergy
- MeSH:
Anaphylaxis*;
Basophils*;
Cephalosporins;
Drug Hypersensitivity;
Humans;
In Vitro Techniques;
Intradermal Tests;
Methods;
Skin;
Skin Tests
- From:Allergy, Asthma & Immunology Research
2016;8(6):541-544
- CountryRepublic of Korea
- Language:English
-
Abstract:
The basophil activation test (BAT) has been suggested as a complementary method for diagnosing drug allergies. The aim of this study was to evaluate the clinical utility of this test in patients with drug-induced anaphylaxis. In total, 19 patients, all of whom had a history of moderate to severe anaphylaxis, were enrolled. None of the causative drugs had available in vitro tests or reliable skin tests; these drugs included, among others, first and second-generation cephalosporins, H2 blockers, and muscle relaxants. The BAT yielded positive results in 57.9% of the cases, which was similar those results of skin prick and intradermal tests (42.1% and 57.9%, respectively). When basophils were double labelled with CD63 and CD203c, both of which are basophil activation markers, the positive rate was increased from 57.9% to 73.7%. Therefore, the results of this study confirm that the BAT is a quick, reliable, and safe diagnostic tool for patients with drug-induced anaphylaxis.
