Correlation between total MRI burden and serum uric acid level in patients with cerebral small vessel disease and its gender differences
10.3760/cma.j.cn371468-20210224-00104
- VernacularTitle:脑小血管病患者磁共振总负担与血清尿酸水平的相关性及性别差异
- Author:
Siqi CHENG
1
;
Wenhui ZHANG
;
Hebo WANG
;
Yanhong DONG
;
Zhenbiao ZHAO
;
Wei JIN
;
Hanlei PEI
;
Yan ZHAO
;
Yaxin DUAN
;
Peiyuan LYU
Author Information
1. 河北医科大学研究生学院，石家庄 050017
- Keywords:
Cerebral small vessel disease;
Uric acid;
Total MRI burden;
Gender
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2021;30(9):800-805
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between total MRI burden and serum uric acid level in patients with cerebral small vessel disease(CSVD) and its gender differences.Methods:A total of 217 patients with CSVD were retrospectively included as the research objects, and the clinical data such as serum uric acid value were collected.The imaging findings of patients with CSVD were evaluated by MRI, and the total MRI burden score of CSVD was calculated.According to the total MRI burden score of CSVD, patients with CSVD were divided into mild-to-moderate burden group ( n=133) and severe burden group ( n=84). SPSS 20.0 software was used for data analysis and processing.Logistic regression was used to analyze the relationship between uric acid and the total MRI burden score of CSVD. Results:The serum uric acid of severe burden group was higher than that of mild-to-moderate burden group((326.94±70.95)μmol/L, (293.42±80.52)μmol/L, P=0.002). The multivariate logistic regression analysis showed that the elevated level of serum uric acid was an independent risk factors for total MRI burden of CSVD ( β=0.005, OR=1.005, 95% CI=1.001-1.009, P=0.019). The patients with CSVD were equally divided into four group based on the serum uric acid concentration.After controlling the confounding factors, with the increase of uric acid level, the risk of aggravating total MRI burden score of CSVD increased, and the difference was statistically significant( P=0.001). Serum uric acid(for each quartile increase)was an independent risk factor for total MRI burden in male patients with CSVD( β=0.482, OR=1.619, 95% CI=1.125-2.330, P=0.010), while there was no significant difference in female patients( P=0.070). Conclusion:Serum uric acid level is a risk factor for increasing the total MRI burden in male patients with CSVD, but this effect is not found in female patients with CSVD.
