Hyperpolarization-activated cyclic nucleotide gated cation channels and substances addiction
10.3760/cma.j.cn371468-20210423-00224
- VernacularTitle:超极化激活的环核苷酸门控阳离子通道与物质成瘾
- Author:
Qigang SHU
1
;
Hongming YE
;
Yongli LU
;
Zicheng LI
Author Information
1. 三峡大学医学院机能学系，宜昌 443002
- Keywords:
Substances addiction;
Hyperpolarization-activated cyclic nucleotide gated cation channels;
Neuron excitability
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2021;30(8):764-768
- CountryChina
- Language:Chinese
-
Abstract:
Substances addiction is one of the important factors that deeply affect human health.At present, there is still lack of effective treatment drugs in the clinic.Exploring mechanisms of substances addiction, finding new therapeutic targets and developing effective therapeutic drugs are important issues to be solved.Hyperpolarization-activated cyclic nucleotide gated cation channels (HCN channels) participate in many advanced brain activities and are closely related to the occurrence and progression of various brain diseases.Among them, the researches on the role and mechanism of HCN channels in substances addiction are gradually gaining attention.Reviewing the researches regarding substances addiction, abnormal function and abnormal expression of HCN channels were observed in many brain regions under the condition of psychoactive substances addiction.However, it has not yet been able to fully understand the mechanism and the behavioral consequences of this change.Therefore, we review the neurobiological mechanisms of HCN channels in substances addiction induced by opioids, cocaine, cannabis, amphetamines, alcohol and tobacco, in order to provide new ideas for the mechanism researches and treatment of substance addiction.
