Emotional face processing in patients with social anxiety disorder: an activation likelihood estimation meta-analysis
10.3760/cma.j.cn371468-20210418-00210
- VernacularTitle:社交焦虑障碍患者情绪面孔加工的脑区激活似然估计分析
- Author:
Rui LI
1
;
Guangming RAN
;
Qi ZHANG
Author Information
1. 西华师范大学教育学院心理系，南充 637002
- Keywords:
Social anxiety disorder;
Face processing;
Emotional face;
Functional magnetic resonance imaging;
Activation likelihood estimation
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2021;30(7):659-664
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relevant brain regions of face/non-face processing, and face processing under different emotional valence in patients with social anxiety disorder(SAD).Methods:PubMed, Medline, ScienceDirect, CNKI and other databases were retrieved, and 31 peer-reviewed emotional face studies of SAD patients were obtained (facial and non-facial processing: 13 literatures, 481 subjects, 161 foci; face processing with different emotional titers: 18 literatures, 586 subjects, 331 foci). Cluster-level family-wise error (FWE, P<0.05) based coordinates of Talairach space was adopted. Results:Face processing in SAD patients activated the left amygdala (x=-18, y=-8, z=-12), the right amygdala (x=26, y=0, z=-20), the entorhinal cortex (Brodmann area 28, x=16, y=-8, z=-10) and the medial prefrontal cortex (Brodmann area 10, x=2, y=44, z=-8). In addition, when SAD patients processed negative faces, the left amygdala (x=-26, y=0, z=-16), the right amygdala (x=26, y=0, z=-12), the left medial globus pallidus (x=-20, y=-10, z=-6) and right medial globus pallidus (x=20, y=-10, z=-6) had strong activation, which fear faces activated bilateral amygdala (left: x=-28, y=0, z=-16, right: x=28, y=-2, z=-12) and angry faces activated the medial globus pallidus (x=20, y=-8, z=-6).Conclusion:There are specific neural mechanisms for face processing in patients with SAD.Bilateral amygdala, entorhinal cortex and medial prefrontal cortex are key brain regions for face processing.The amygdala and medial globus pallidus are important neural regions for face processing of negative emotions.
