Characteristics of resting-state brain voxel-mirrored homotopic connectivity in patients with chronic schizophrenia
10.3760/cma.j.cn371468-20210122-00034
- VernacularTitle:慢性精神分裂症患者静息态脑镜像同伦连接研究
- Author:
Weiliang YANG
1
;
Yongying CHENG
;
Yan LI
;
Shuli XU
;
Chuanjun ZHUO
;
Jie LI
Author Information
1. 天津医科大学精神卫生临床学院 300070
- Keywords:
Chronic schizophrenia;
Functional magnetic resonance imaging;
Voxel-mirrored homotopic connectivity;
Gray matter volume
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2021;30(6):510-514
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the brain characteristics of chronic schizophrenia by voxel-mirrored homotopic connectivity (VMHC).Methods:Forty seven patients with chronic schizophrenia from Tianjin Anding Hospital and 31 healthy controls from nearby communities were included in the study. The MRI data of the subjects were collected by Siemens Skyra 3.0 T MRI.Positive and negative symptoms scale (PANSS) was used to assess the illness severity of patients with chronic schizophrenia.SPM12 was used to process the collected MRI data. DPARSF was used to calculate the VMHC values of subjects in the two groups. The independent sample t test based on SPM12 was used to compare the VMHC values of the two groups. The significant brain regions in VMHC were regarded as regions of interest (ROI), and VBM8 was used to further analyze the gray matter volume of the ROI of the two groups. Results:Compared with healthy controls, the patients with chronic schizophrenia demonstrated decreased VMHC mainly located in lingual gyrus(voxel=208, T=4.98), occipital middle occipital gyrus(voxel=156, T=3.75) and postcentral gyrus(voxel=237, T=4.36) (FDR correction, q=0.05). Compared with healthy controls, the gray matter volumes in bilateral lingual gyrus(left(0.0034±0.0008), (0.0028±0.0013), t=-2.141, P=0.037; right(0.0025±0.0006), (0.0020±0.0011), t=2.268, P=0.028) and postcentral gyrus((0.0432±0.0051), (0.0372±0.0162), t=-2.070, P=0.045) increased, but non-significant change in postcentral gyrus of the patients with chronic schizophrenia. Conclusion:The abnormal VMHC mainly locate in lingual gyrus, middle occipital gyrus and postcentral gyrus in patients with chronic schizophrenia.
