Advances in research on the relationship between changes in cellular metabolism and lung diseases
10.3760/cma.j.cn121430-20210119-00081
- VernacularTitle:细胞代谢变化与肺部疾病关系研究进展
- Author:
Menglu XU
1
;
Yiding ZUO
;
Li ZHOU
;
Chunling JIANG
Author Information
1. 四川大学华西医院麻醉科，成都 610041
- Keywords:
Cellular metabolism;
Lung;
Glycolysis;
Energy;
Respiratory disease
- From:
Chinese Critical Care Medicine
2021;33(9):1145-1148
- CountryChina
- Language:Chinese
-
Abstract:
As the place for gas exchange, the lungs are metabolically active, and their energy consumption are essential for regulating common cell functions and maintaining the unique function of lung tissues to synthesize pulmonary surfactants. The metabolic pathways of pulmonary cells mainly include glycolysis, pentose phosphate pathway, and tricarboxylic acid cycle. Recent studies have found that changes in pulmonary cells metabolism are closely related to a variety of lung diseases. Herein, we review the main pathways of pulmonary cells metabolism and the relationship between changes in cell metabolism and the four lung diseases of chronic obstructive pulmonary disease (COPD), asthma, idiopathic pulmonary fibrosis (IPF), and pulmonary hypertension (PH), to find new ways to treat lung diseases.
