Application progress of metabonomics evaluation methods in bronchial asthma
10.3760/cma.j.cn121430-20210128-00157
- VernacularTitle:代谢组学评价方法在支气管哮喘研究中的应用进展
- Author:
Huiru LI
1
;
Chunlei DUAN
;
Linqiong ZHOU
;
Minghang WANG
Author Information
1. 河南中医药大学第一临床医学院，郑州 450000
- Keywords:
Metabonomics;
Bronchial asthma;
Pathogenesis;
Diagnosis;
Evaluation of severit
- From:
Chinese Critical Care Medicine
2021;33(8):1021-1024
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma (asthma) is a complex heterogeneous disease, with a high rate of missed diagnosis and misdiagnosis. Repeated attacks of bronchial asthma can cause complications such as chronic obstructive pulmonary disease, emphysema, and pulmonary heart disease. In recent years, mass-spectrometry-based metabolomics has developed rapidly. It can sensitively identify metabolic fluctuations and pathological changes in patients with asthma. By analyzing the molecules produced by various metabolic pathways, it can help us to find relevant biomarkers and provide a better method for early diagnosis and severity assessment of asthma. We reviewed and analyzed the literature of metabolomics technology in disease progression, early diagnosis and severity assessment, so as to provide reference for asthma research.
