Research progress of mitochondrial unfolded protein response in myocardial ischemia/reperfusion injury
10.3760/cma.j.cn121430-20210316-00384
- VernacularTitle:线粒体未折叠蛋白反应在心肌缺血/再灌注损伤中的研究进展
- Author:
Xiaoqu TANG
1
;
Xiaoyun FU
;
Bao FU
;
Xinxin LIU
Author Information
1. 遵义医科大学附属医院重症医学科，贵州遵义 563000
- Keywords:
Myocardial ischemia/reperfusion injury;
Mitochondrial unfolded protein response;
Myocardial protection
- From:
Chinese Critical Care Medicine
2021;33(8):1007-1010
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial unfolded protein response (UPR mt) is a protein-toxic stress response, which regulates the communication from mitochondria to the nucleus. It is activated when a large number of unfolded or misfolded proteins accumulate in the mitochondria. The activation of UPR mt increases the expression of a series of chaperones and proteases, and maintains the homeostasis and function of mitochondrial proteins. Mitochondria play an important role in maintaining cardiomyocyte homeostasis. The damage of myocardial mitochondria leads to the metabolic disorder of cells suffering from ischemia/reperfusion injury. It is the key mechanism of myocardial cell death. This article mainly reviews the regulatory pathway of UPR mt and the research progress of UPR mt in myocardial ischemia/reperfusion injury (MIRI), in order to provide new ideas for the treatment of MIRI.
