Current progress and future directions of basic research on sepsis
10.3760/cma.j.cn121430-20210126-00132
- VernacularTitle:脓毒症基础研究的进展及未来方向
- Author:
Xiaoting ZHANG
1
;
Wentao JI
;
Lulong BO
;
Jinjun BIAN
;
Xiaoming DENG
Author Information
1. 海军军医大学第一附属医院麻醉学部，上海 200433
- Keywords:
Sepsis;
Research;
Microbiota;
Epigenetics
- From:
Chinese Critical Care Medicine
2021;33(8):919-921
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, of which the pathogenesis is complex and the mortality rate is high. However, current basic research is facing the dilemma of high heterogeneity and difficult translation to clinical practice. In-depth basic research is one of the most important ways to break through the "bottleneck" of clinical diagnosis and treatment of sepsis. The purpose of this review is to analyze the current progress and challenges in the field of basic research on sepsis, and look forward to the potential research directions in the future. Cell function, energy metabolism, microbiota, epigenetics and recovery period of sepsis may be the research priorities.
