Research progress on release mechanism of high mobility group protein B1 in acute respiratory distress syndrome
10.3760/cma.j.cn121430-20200421-00316
- VernacularTitle:高迁移率族蛋白B1在ARDS中的释放机制研究进展
- Author:
Xiaoyi SHU
1
;
Shaohui FAN
;
Yu XU
;
Le BI
;
Youxia LI
;
Jinrui DONG
;
Hongman WANG
Author Information
1. 遵义医科大学第五附属（珠海）医院呼吸与危重症医学科，广东珠海 519100
- Keywords:
High mobility group protein B1;
Acute respiratory distress syndrome;
Inflammation;
Macrophage
- From:
Chinese Critical Care Medicine
2021;33(7):889-893
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group protein B1 (HMGB1), a highly conversed non-histone nucleoproteins with strong pro-inflammatory property, is one of the inflammatory mediator of the acute respiratory distress syndrome (ARDS). Numerous studies have confirmed that HMGB1 regulates ARDS by binding to receptor for advanced glycation end product (RAGE), Toll-like receptor (TLR) and etc. And it can significantly increase the mortality of ARDS. But the mechanism of HMGB1 release is still unclear. This study focuses on the HMGB1 release progress, which connected with Janus kinases/signal transducer and activator of transcription (JAK/STAT), nuclear factor-κB (NF-κB), Notch, inflammasome, tumor necrosis factor (TNF), mitogen-activated protein kinase (MAPK), reactive oxygen species (ROS), peroxisome proliferator-activated receptor (PPAR) and other signaling or dependent pathways in ARDS.
