Research progress on regulated necrosis in acute kidney injury

VernacularTitle:调节性坏死在急性肾损伤中的相关研究进展
Author: Yi LU ¹ ; Fangfang ZHOU ; Qun LUO
Author Information

1. 宁波大学医学院，浙江宁波　315000
Keywords: Regulated necrosis; Necroptosis; Pyroptosis; Ferroptosis; Acute kidney injury
From: Chinese Critical Care Medicine 2021;33(7):885-888
CountryChina
Language:Chinese
Abstract: Regulated necrosis is a newly discovered new cell death pathway, including necroptosis, pyroptosis and ferroptosis. It has been reported to play a key role in acute kidney injury (AKI) induced by ischemia/reperfusion, cisplatin and other drugs, and rhabdomyolysis. Studying the role of regulated necrosis-related pathways in AKI is expected to provide a new direction for clarifying the pathogenesis and treatment of AKI, with potential therapy and application prospects. In this review, we summarize the related signaling pathways of necroptosis, pyroptosis and ferroptosis, and the related research progress in AKI, in order to provide potential targets for the prevention and treatment of AKI.