Research of progress of pyruvate dehydrogenase complex in sepsis metabolism

VernacularTitle:脓毒症代谢中丙酮酸脱氢酶复合体调控机制的研究进展
Author: Jie WU ¹ ; Weijin ZHANG ; Shucan ZHAO ; Jianqun LIN ; Shijian HU ; Liangfeng MAO ; Sheng AN
Author Information

1. 南方医科大学南方医院重症医学科，广东广州　510515
Keywords: Sepsis; Pyruvate dehydrogenase complex; Metabolism; Drug
From: Chinese Critical Care Medicine 2021;33(6):765-768
CountryChina
Language:Chinese
Abstract: Sepsis is a critical illness with high morbidity and mortality. Anaerobic glycolysis plays an important role in the pathogenesis of sepsis. Pyruvate dehydrogenase complex (PDHC) serves as a key regulator during sepsis. With PDHC dephosphorylation and deacetylation, PDHC activity is upregulated, allowing pyruvate translocate to mitochondria in aerobic condition, preceding the production of acetyl-CoA to accelerate aerobic oxidation. Activation of PDHC improves the prognosis of sepsis through regulating the balance of lactate, release of inflammatory factors and energy metabolism. A variety of remedies can improve the prognosis of patients with sepsis by up-regulating the activity of PDHC, including dichloroacetate (DCA), vitamin B1, milrinone, tumor necrosis factor binding protein, and ciprofloxacin.This article reviews the role and the regulatory mechanism of PDHC and signal pathway in the sepsis metabolism, in order to innovate treatment for sepsis and multiple organ dysfunction.