Research progress on the mechanism of two-component systems in regulating carbapenem resistance of Klebsiella pneumonia

VernacularTitle:双组分系统调控肺炎克雷伯菌碳青霉烯耐药机制的研究进展
Author: Zhaoyan CHEN ¹ ; Zhidan QIN ; Liangyan JIANG ; Zhanhong TANG
Author Information

1. 广西医科大学第一附属医院重症医学科，南宁　530021
Keywords: Klebsiella pneumoniae; Carbapenem resistance; Two-component system; Research progress
From: Chinese Critical Care Medicine 2021;33(6):761-764
CountryChina
Language:Chinese
Abstract: Carbapenem-resistant Klebsiella pneumoniae (CRKP) leads to high mortality of infected patients. How to deal with CRKP is an urgent problem in clinical practice, and it is imperative to carry out researchon carbapenem resistance mechanism of CRKP. The two-component systems (TCSs) areassociated with the development of drug resistance in a variety of bacteria, and TCSs were expected to be important therapeutic targets for CRKP. Therefore, this article reviewed the mechanisms of TCSs in the regulation of CRKP from the following several aspects: common mechanisms of carbapenem resistance of CRKP, research progress in drug resistance of TCSs, relationships between Klebsiella pneumoniae and TCSs, and so on. It may provide some research ideas for future research and the references for clinical diagnosis and treatment.