Research progress of extracellular vesicle microRNA in acute lung injury
10.3760/cma.j.cn121430-20200727-00544
- VernacularTitle:胞外囊泡微小RNA在急性肺损伤中的相关研究进展
- Author:
Yingcong REN
1
;
Miao CHEN
;
Xinxin LIU
;
Banghai FENG
Author Information
1. 遵义医科大学附属医院重症医学科，贵州遵义 563000
- Keywords:
Acute lung injury;
Extracellular vesicle;
MicroRNA;
Stem cell
- From:
Chinese Critical Care Medicine
2021;33(5):633-637
- CountryChina
- Language:Chinese
-
Abstract:
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are characterized by the destruction of the barrier function of alveolar epithelial cells and capillary endothelial cells and the recruitment of inflammatory cells, which leads to alveolar and interstitial edema, hyaline membrane formation and inflammatory infiltration of the lungs, etc. The mechanism is not completely defined. The current treatment plan focuses on comprehensive treatments such as ventilator support treatment, fluid management, and nutritional support, but the prognosis is still poor. Studies have shown that extracellular vesicle microRNA (miRNA) from different sources participate in regulating the function of epithelial cells, endothelial cells and phagocytes in different ways, thus aggravating or improving ALI, and have diagnostic, differential diagnosis and the therapeutic value. In this article, the mechanism, diagnostic and differerntial value of extracellular vesicle miRNA from different sources in ALI and the therapy of extracellular vesicle miRNA from stem cell in ALI are reviewed.
