Relationship of single nucleotide polymorphisms and genetic susceptibility to sepsis

VernacularTitle:单核苷酸多态性与脓毒症遗传易感性的关系
Author: Mengqiu SHENG ¹ ; Yu ZHANG ; Tieying HOU
Author Information

1. 广东省人民医院（广东省医学科学院），广东省心血管病研究所，广州　510080
Keywords: Single nucleotide polymorphism; Sepsis; Genetic susceptibility
From: Chinese Critical Care Medicine 2021;33(5):630-632
CountryChina
Language:Chinese
Abstract: Sepsis is a clinical syndrome caused by the host reaction disorder induced by infection, which leads to serious organ function damage. Sepsis is a serious disease with high mortality, which is the main reason of death caused by infection. Single nucleotide polymorphisms (SNP) is one of the most common genetic variants in human, and is closely related to the genetic susceptibility, early diagnosis, disease development and prognosis of sepsis. This article makes a review on the relationship between CD14, Toll like receptor (TLR), tumor necrosis factor (TNF), interleukins (IL-1 and IL-6), plasminogen activator inhibitor 1 (PAI-1), angiotensin converting enzyme (ACE) and other gene polymorphisms and genetic susceptibility of sepsis, in order to affect in sepsis on the early prediction, diagnosis, and treatment.