Recent progress of antimicrobial peptides in sepsis treatment

VernacularTitle:抗菌肽在脓毒症治疗中的应用进展
Author: Zhongmin FAN ¹ ; Yi LI ; Mei TANG ; Zongping FANG ; Xijing ZHANG
Author Information

1. 解放军空军军医大学第一附属医院重症医学科，陕西西安　710000
Keywords: Antimicrobial peptide; Sepsis; Host defense peptide; Synthetic antimicrobial peptide
From: Chinese Critical Care Medicine 2021;33(5):626-629
CountryChina
Language:Chinese
Abstract: Sepsis is a life-threatening organ dysfunction due to the dysregulation of host responses during infection. Severe systemic inflammatory response syndrome (SIRS) is the primary pathophysiological feature. Despite the classical antibiotic therapies play an important role in sepsis, the emergence of multi-resistant bacteria makes a greater challenge in clinical. Antimicrobial peptides (AMP) which consist of small cationic peptides, can be found in most organisms. As a result of their board-spectrum antibacterial activities and immunoregulatory functions, AMPs may have an excellent effect on the treatment of sepsis. In this review, we will discuss the basic role of AMPs in sepsis treatment and their application prospect and the challenges which need to be resolved in order to provide ideas for clinical application of AMPs.