Pathogenesis, diagnosis, and management for sepsis: update progress and scientific problems
10.3760/cma.j.cn121430-20210326-00441
- VernacularTitle:关于脓毒症的发生机制与识别和干预
- Author:
Yingyi LUAN
1
;
Xiaomei ZHU
;
Yongming YAO
Author Information
1. 解放军总医院第四医学中心、医学创新研究部转化医学研究中心，北京 100048
- Keywords:
Sepsis;
Regulatory mechanism;
Prediction;
Treatment
- From:
Chinese Critical Care Medicine
2021;33(5):513-516
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is caused by various pathogens and toxic factors, which can lead to multiple organ dysfunction. The underlying mechanism of sepsis appears to be complex, involving epigenetic reprogramming, metabolic failure, immune dysfunction, neuroendocrine system disorders, coagulation abnormalities, tissue or organ failure, and many other scientific issues. With our deep understanding of the host reaction and development of sepsis, it is of great significance to explore predicative markers and therapeutic targets according to the atypical characteristics of sepsis, thereby contributing to the reduction of morbidity and mortality of sepsis.
