The application progress of fluid de-escalation therapy in abdominal infection-induced septic shock
10.3760/cma.j.cn121430-20200714-00519
- VernacularTitle:液体治疗降阶梯策略在腹腔脓毒性休克中的应用进展
- Author:
Zhizhao JIANG
1
;
Yuqi LIU
;
Jian'an REN
Author Information
1. 福建医科大学附属第二医院重症医学科，福建泉州 362000
- Keywords:
Fluid de-escalation therapy;
Fluid therapy;
Abdominal infection;
Septic shock;
Fluid overload
- From:
Chinese Critical Care Medicine
2020;32(11):1403-1408
- CountryChina
- Language:Chinese
-
Abstract:
After adequate fluid resuscitation in the early stage of septic shock, excessive accumulation of fluid in the body leads to organ dysfunction, which prolongs hospitalization, mechanical ventilation time, and renal replacement therapy time, and is associated with poor prognosis. The fluid de-escalation therapy is an important fluid management strategy performed in the late stage of septic shock. It aims to clear excess fluid by restricting fluid infusion, using diuretics and renal replacement therapy to achieve a negative fluid balance. The fluid de-escalation therapy contributes to improve clinical outcome of septic shock patients and reduce the mortality. This review mainly discusses the current researches and application progress of the fluid de-escalation therapy of abdominal infection-induced septic shock through clarifying its origin, time and endpoint, method of the therapy, the relationship with the control of the source of abdominal infection and its impact on organ function and clinical outcome. Our study intends to provide guidance for the treatment of abdominal infection-induced septic shock in the late stage, and explore the novel research directions.
