Expert consensus on clinical application of intravenous alanyl-glutamine dipeptide
10.3760/cma.j.cn115822-20210521-00113
- VernacularTitle:静脉用丙氨酰-谷氨酰胺双肽临床应用专家共识（2021）
- Author:
Mingwei ZHU
1
;
Hua YANG
;
Wei CHEN
;
Xinying WANG
;
Hua JIANG
;
Yun TANG
;
Zhenyi JIA
;
Hua ZHOU
;
Bin ZHAO
;
Liru CHEN
;
Weiming KANG
Author Information
1. 北京医院 普通外科 肝胆胰外科，国家老年医学中心，中国医学科学院老年医学研究院 100730
- Keywords:
Glutamine;
Alanyl-glutamine dipeptide;
Intestinal barrier function;
Complications of infection
- From:
Chinese Journal of Clinical Nutrition
2021;29(4):193-200
- CountryChina
- Language:Chinese
-
Abstract:
Alanyl-glutamine dipeptide is an important component in parenteral nutrition, which can be decomposed into alanine and L-glutamine in vivo. It plays multiple functions including maintaining intestinal barrier, improving immunity, promoting protein synthesis, and regulating the production and release of inflammatory mediators. Substantial clinical evidences have demonstrated its favorable effectiveness and safety. Rational application of alanyl-glutamine dipeptide can reduce postoperative complications, shorten hospital stay and save medical costs. There are still controversies at home and abroad on the applicable population and dosage of alanyl-glutamine dipeptide. Chinese Society of Parenteral and Enteral Nutrition organized China's experts of related disciplines to compile international standards in accordance with the latest guidelines and consensus, so as to achieve the goal of standardized application and patient benefits.
