Risk factors, etiology, diagnosis and treatment of hyperuricemia and gout in children and adolescents
10.3760/cma.j.cn115822-20210225-00043
- VernacularTitle:儿童及青少年高尿酸血症和痛风的危险因素、病因及诊治策略
- Author:
Shihan WANG
1
;
Tao YUAN
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院内分泌科，国家卫生健康委员会内分泌重点实验室 100730
- Keywords:
Children;
Adolescent;
Hyperuricemia;
Gout
- From:
Chinese Journal of Clinical Nutrition
2021;29(3):163-170
- CountryChina
- Language:Chinese
-
Abstract:
Although the issue of hyperuricemia (HUA) and gout in adults has attracted much attention in recent years, our understanding of HUA and gout in children and adolescents is still very limited. HUA is an important metabolic disease in children and adolescents, who are more likely to develop complications such as renal dysfunction than adult patients. Positive family history, growth history and obesity are risk factors for HUA in children and adolescents. The etiology of HUA in children and adolescents is different from that in adults, including secondary factors, genetic diseases and other diseases complicated with hyperuricemia and gout. Similar to the treatment strategies in adults, it is very important to control body weight and reduce the intake of high purine and high fructose diet on the premise of ensuring normal growth and development. If necessary, uric-acid-lowering drugs with favorable safely profiles in children and adolescents should be used with monitoring of renal uric acid excretion.
