Research progress on characteristics of gastrointestinal flora in patients with Crohn's disease and the efficacy of fecal microbiota transplantation
10.3760/cma.j.cn115822-20210123-00019
- VernacularTitle:克罗恩病患者消化道菌群特征及粪菌移植治疗疗效的研究进展
- Author:
Kai XIA
1
;
Renyuan GAO
;
Huanlong QIN
;
Lu YIN
Author Information
1. 同济大学附属第十人民医院腹部外科疑难诊治中心，上海 200072
- Keywords:
Crohn's disease;
Digestive tract;
Flora characteristics;
Fecal microbiota transplantation
- From:
Chinese Journal of Clinical Nutrition
2021;29(2):109-113
- CountryChina
- Language:Chinese
-
Abstract:
Crohn's disease (CD) is a chronic nonspecific inflammatory bowel disease that can involve the whole digestive tract. At present, the pathogenesis is believed to be mainly related to environment, genetics and intestinal microecology changes. Compared with healthy people, CD patients demonstrate different degrees of flora imbalance in the digestive tract, and the flora composition varies across different regions. In recent years, reconstruction of gastrointestinal microecological balance has become the focus of research. Fecal microbiota transplantation as a new treatment strategy has been gradually applied in clinical practice. Here we reviewed the changes of flora across different regions of digestive tract in patients with CD and the relevant pathogenic mechanism, as well as the progress of fecal microbiota transplantation in the treatment of CD.
