Relevance of CAR genetic polymorphism and individual therapy
- VernacularTitle:组成性雄烷受体遗传多态性与个体化治疗
- Author:
Wanhui WEI
1
;
Ling LI
;
Mingyang HE
;
Huijia ZHAO
;
Qian XU
;
Yuying SHI
;
Jiang YUE
;
Yanfeng WANG
;
Qifa YE
Author Information
1. 武汉大学中南医院,武汉大学肝胆疾病研究院,武汉大学移植医学中心,移植医学技术湖北省重点实验室,武汉430071,湖北
- Keywords:
constitutive androstane receptor (CAR);
polymorphism;
material metabolism
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2017;22(12):1432-1440
- CountryChina
- Language:Chinese
-
Abstract:
Regulating phase Ⅰ and Ⅱ enzyme,drug transporters and constitutive androstane receptor (CAR) play an important role in dug metabolism and keeping balance on the levels of glucose,lipids and hormone in serum.As a hub of material metabolism within body,CAR can affect the efficacy of various drugs and be involved in many common metabolic diseases.Studying its polymorphism is referential for explaining the individual difference genetically and predicting the occurrence and development of diseases.This review focuses on the correlation between the CAR polymorphism and metabolic,which provides evidence for predicting the development of disease and choosing clinical drug dosage.
