Clinical implications of circulating miRNA-101 expression level in patients with newly diagnosed type 2 diabetes mellitus
- VernacularTitle:初诊2型糖尿病患者循环miRNA-101的表达变化及临床意义
- Author:
Xiang KONG
1
;
Qiang HUA
;
Xiangjian MENG
;
Xinming YAO
;
Yong WANG
;
Libin XIA
Author Information
1. 皖南医学院第一附属医院弋矶山医院内分泌科,芜湖241001,安徽
- Keywords:
newly diagnosed type 2 diabetes mellitus;
glycosylated hemoglobin A1c;
miRNA-101
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2017;22(12):1406-1409
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the serum miRNA-101 expression level in patients with newly diagnosed type 2 diabetes mellitus (T2DM),and to evaluate the clinical implications of miRNA-101 expression level variation.METHODS:qRT-PCR was used to determine the serum miRNA-101 expression level.Pearson correlation analysis was performed to observe the relationship between two variables.Multiple stepwise linear regression analysis was used to assess the association of serum miRNA-101 level and other parameters.RESULTS:Serum miRNA-101 level in patients with newly diagnosed T2DM was significantly higher than that in control subjects (P ＜ 0.05).The serum level of miRNA-101 was positively correlated with the glycosylated hemoglobin A1c (HbA1c,P ＜0.05).Multiple linear regression analysis revealed that the circulating miRNA-101 was in significant positive correlation with HbA1c (P ＜ 0.05) after adjustment for age,sex and body weight.CONCLUSION:Enhanced circulating miRNA-101 level in newly diagnosed T2DM patients may be associated with elevation of HbA1 c.
