Relationship of Fusobacterium nucleatum levels in gut microbiota with type 2 diabetes mellitus in Uygurs of Xinjiang
- VernacularTitle:新疆维吾尔族粪样中具核梭杆菌水平与2型糖尿病的相关性研究
- Author:
Chanyue WANG
1
;
Ye WANG
;
Peipei ZHANG
;
Mingyue CHEN
;
Hao YANG
;
Manli ZHU
;
Linlin LI
Author Information
1. 新疆医科大学药理教研室,乌鲁木齐830054,新疆
- Keywords:
Fusobacterium nucleatum;
type 2 diabetes mellitus;
quantitative real-time PCR
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2017;22(12):1321-1325
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To detect the levels of Fusobacterium nucleatum in Uygurs of Xinjiang with normal glucose tolerance (NGT) or type 2 diabetes mellitus (T2DM) and to analyze the correlation between Fusobacterium nucleatum level and type 2 diabetes mellitus.METHODS:Blood and fecal samples were collected from Uygurs of Xinjiang with NGT or T2DM respectively.16SrDNA quantitative real-time PCR technology was used to detect the levels of Fusobacterium nucleatum in fecal samples.The correlations between Fusobacterium nucleatum and BMI,TC,TG,HDL and LDL levels were analyzed by Pearson.RESULTS:(1) The levels of Fusobacterium nucleatum in Uygurs T2DM group were significantly higher than those in Uygurs NGT group (P =0.011).(2) Fusobacterium nucleatum was positively correlated with the levels of BMI (r =0.335,P =0.049),TC(r =0.472,P =0.011)and LDL(r =0.368,P =0.029).CONCLUSION:The levels of Fusobacterium nucleatum may be closely related to lipid metabolism of T2DM in Uygurs.
