Increment of Telomerase Activity with Breast Cancer Progression.
- Author:
Kyu Hyun PARK
1
;
Sun Young RHA
;
Tae Soo KIM
;
Byung Chan LEE
;
Sei Ho PARK
;
Hyun Cheol CHUNG
;
Won Young LEE
;
Joo Hang KIM
;
Jae Kyung ROH
;
Kyong Sik LEE
;
Jin Sik MIN
;
Byung Soo KIM
Author Information
1. Yonsei Cancer Research Center, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Breast cancer;
Telomerase
- MeSH:
Breast Neoplasms*;
Breast*;
Lymph Nodes;
Mitosis;
Neoplasm Metastasis;
Telomerase*
- From:Journal of the Korean Cancer Association
1997;29(6):1032-1040
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We studied the telomerase activity in normal and cancer tissues of the breast and then compared it to the clinical parameters. MATERIALS AND METHODS: 36 paired normal and cancerous breast tissues were assayed for telomerase activity by PCR-based TRAP assay (telomeric repeat amplification protocol). In 17 cancer tissues, flow cytometric analysis for S-phase fraction was done. RESULTS: None of the normal breast tissue expressed telomerase activity while 23 out of 26 breast cancer tissue expressed telomerase activity (92%). Clinical parameters such as T-factor, tumor grade, hormone receptor expression, mitosis, S-phase fraction did not correlate with telomerase expression. However, telomerase acitvity increased with cancer progression such as; in a state of lymph node metastasis and in an advanced pathological stage. CONCLUSION: Telomerase activity was expressed only from cancer tissues. And this expression increased with cancer progression suggesting a possible therapeutic target in breast cancer.
