Effect of blood pressure management on prognosis of cerebral infarction after intravenous thrombolytic therapy
10.3760/cma.issn1008-6706.2021.07.003
- VernacularTitle:血压调控对静脉溶栓治疗脑梗死患者预后影响的研究
- Author:
Guanrong ZHENG
1
Author Information
1. 杭州市富阳区第一人民医院神经外科 311400
- Keywords:
Brain infarction;
Blood pressure determination;
Antihypertensive agents;
Tissue plasminogen activator;
Thrombolytic therapy;
Veins;
Cerebrovascular circulat
- From:
Chinese Journal of Primary Medicine and Pharmacy
2021;28(7):969-972
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of blood pressure management on the prognosis of acute cerebral infarction after intravenous thrombolytic therapy.Methods:The clinical data of 60 patients with acute cerebral infarction who received intravenous thrombolytic therapy in The First People's Hospital of Fuyang District, Hangzhou, China between September 2017 and June 2019 were retrospectively analyzed. These 60 patients were divided into groups A and B according to different treatment methods ( n = 30/group). Patients in the group A received intravenous thrombolytic therapy with recombinant tissue plasminogen activator and those in the group B received intravenous thrombolysis with recombinant tissue plasminogen activator in combination with antihypertensive treatment. All patients were treated for 2 courses of treatment (14 days) and followed up for 3 months. Blood pressure, cerebral blood flow and prognosis were compared between groups A and B. Results:After 24 hours of treatment, there were no significant differences in blood pressure and cerebral blood flow between groups A and B (both P < 0.05). In the group B, modified Rankin Scale score ≥ 2 points was found in 1 (3.3%) patient and intracranial hemorrhage in 0 (0.0%) patient, which were significantly lower than 12 (40.0%) and 6 (20.0%) patients, respectively in the group A ( χ2 = 29.897, 19.573, both P < 0.05). Total effective rate in the group B was significantly higher than that in the group A [96.7% (29/30) vs. 86.67% (26/30), χ2 = 21.302, P < 0.05]. Conclusion:Blood pressure management highly affects the prognosis of cerebral infarction after intravenous thrombolytic therapy. The first 24 hours of intravenous thrombolytic therapy is the optimal time for blood pressure management.
