Research progress of sulfation modification of chondroitin sulfate and chondroitin sulfate preparation in Kashin-Beck disease and osteoarthritis
10.3760/cma.j.cn231583-20210301-00059
- VernacularTitle:硫酸软骨素硫酸化修饰及硫酸软骨素制剂在大骨节病和骨关节炎中的研究进展
- Author:
Yizhen LYU
1
;
Huan DENG
;
Ziwei GUO
;
Jiaxin LIU
;
Yan ZHAO
;
Lichun QIAO
;
Xiang XIAO
;
Yang SHEN
;
Xuan LIU
;
Jing HAN
Author Information
1. 西安交通大学医学部公共卫生学院 710061
- Keywords:
Chondroitin sulfate;
Sulfate modification;
Chondroitin sulfate preparation;
Kashin-Beck disease;
Osteoarthritis
- From:
Chinese Journal of Endemiology
2021;40(11):942-946
- CountryChina
- Language:Chinese
-
Abstract:
Chondroitin sulfate (CS) is a sulfurated glycosaminoglycan, a major component of the extracellular matrix, widely distributed in skin, cartilage and vascular tissue. CS plays an important role in the physiological state regulation of articular cartilage, which affects tensile strength and elasticity of tissues by influencing aggrecan. Previous studies have shown that CS sulfate modification may be related to the growth and development disorders of cartilage tissue and the occurrence of osteoarticular diseases. At the same time, CS is also a common joint supplement, often used in the treatment of osteoarthritis and Kashin-Beck disease. In this paper, the research progress of CS sulfate modification characteristics in Kashin-Beck disease and osteoarthritis and the application of the preparation in the treatment of Kashin-Beck disease and osteoarthritis are reviewed, aiming to provide help for the investigation of the etiology of Kashin-Beck disease and the treatment of osteoarthritis and Kashin-Beck disease.
