Efficacy of levofloxacin and moxifloxacin in the treatment of experimentally infected guinea pigs with Yersinia pestis
10.3760/cma.j.cn231583-20210114-00012
- VernacularTitle:左氧氟沙星和莫西沙星治疗豚鼠实验感染鼠疫的效果观察
- Author:
Jian HE
1
;
Youquan XIN
;
Xiaoyan YANG
;
Sheng LI
;
Qi ZHANG
;
Juan JIN
;
Jianguo YANG
;
Haoming XIONG
;
Ruixia DAI
Author Information
1. 青海省地方病预防控制所鼠疫菌专业实验室，西宁 810021
- Keywords:
Yersinia pestis;
Treatment;
Guinea pigs;
Clinical observation
- From:
Chinese Journal of Endemiology
2021;40(11):880-883
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the efficacy of levofloxacin and moxifloxacin in the treatment of experimental plague in guinea pigs.Methods:A total of 70 SPF guinea pigs, female, weighing 250 to 300 g, were selected and randomly divided into 7 groups according to body weight by random number table. There were 10 guinea pigs in each group: levofloxacin 24, 48, 72 h groups, moxifloxacin 24, 48, 72 h groups (drug treatment was carried out after being infected with Yersinia pestis for 24, 48 and 72 h, respectively) and control group (without treatment). Experimentally infected plague model was established through guinea pigs subcutaneous injection of 141 strains of Yersinia pestis [1 × 10 7 colony forming unit (CFU)]; referring to the adult dose in the "National Pharmacopoeia of the People's Republic of China", the daily dose of guinea pigs was converted by Shi Xinyou's animal conversion coefficient method for treatment, the doses of levofloxacin and moxifloxacin in each guinea pig were 12.0 and 9.6 mg/d, respectively for 9 days. The guinea pigs were killed 9 days after drug withdrawal for bacteriological examination and pathological observation, and the cure rate was calculated. Results:The cure rates of levofloxacin 24, 48 and 72 h groups were 100.0% (10/10), 70.0% (7/10) and 6/6, respectively. The cure rates of moxifloxacin 24, 48 and 72 h groups were 100.0% (10/10), 100.0% (10/10) and 5/7, respectively, and the cure rate of animals in the control group was 0 (0/10). Compared with the control group, there were significant differences in the efficacy of moxifloxacin 24, 48 and 72 h groups and levofloxacin 24, 48 and 72 h groups ( P < 0.05). There was no significant difference between the two drugs at the same starting time ( P > 0.05). Conclusion:The effects of levofloxacin and moxifloxacin on animal plague infection are ideal and the two drugs can be used as a substitute for streptomycin in plague treatment under special circumstances.
