Serum biomarkers of differential metabolism in high iodine diet intervention population
10.3760/cma.j.cn231583-20201118-00298
- VernacularTitle:高碘膳食干预人群血清差异代谢生物标志物研究
- Author:
Yang DU
1
;
Lijun FAN
;
Yanhui GAO
;
Lixiang LIU
;
Dianjun SUN
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心 150081
- Keywords:
High iodine;
Metabonomics;
Biomarker
- From:
Chinese Journal of Endemiology
2021;40(10):775-780
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the serum different metabolites in population of dietary intervention with high iodine.Methods:Thirty-eight healthy volunteers were recruited in Harbin Medical University, all women, aged > 20 years. Dietary intervention was carried out by eating iodine-rich food (kelp) for 11 consecutive days. The effect of intervention was evaluated through urinary iodine test. Peripheral blood was collected, the metabolic alterations associated with high iodine intake before and after intervention were investigated using ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF MSMS). Multivariate statistical analysis was used to screen potential biomarkers. And disturbed metabolic pathway analysis was performed.Results:The medians urinary iodine before and after intervention were 129.48 and 795.94 μg/L, respectively. A total of 20 serum biomarkers were screened and their chemical structures were identified. Glycerol phospholipid metabolic pathway, tryptophan metabolic pathway and pentose and glucuronate interconversions pathway were closely related with high iodine intake (impact value > 0.1).Conclusions:After the intervention of high iodine diet, there are obvious differential metabolites in peripheral blood, which may be used as biomarkers for evaluation of population iodine nutrition. High iodine intake has an impact on metabolic pathway of glycerol phospholipid in human body.
