Genetic regulation of microvascular proliferation under high altitude hypoxia
10.3760/cma.j.cn231583-20200520-00124
- VernacularTitle:高原低氧微血管增生的遗传调控研究进展
- Author:
Mingming ZHU
1
;
Sen CUI
Author Information
1. 青海大学附属医院血液科，西宁 810001
- Keywords:
Hypoxia;
Microvascular proliferation;
Genetic regulation
- From:
Chinese Journal of Endemiology
2021;40(9):771-774
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia is a typical characteristic of the high altitude environment. Chronic hypoxia arises due to the excessive production of erythrocytes, which increases the blood viscosity causing blood flow retardation to exacerbate hypoxic-ischemic injury and eventually angiogenesis. The "blood rich face" of people who have lived in high altitude for a long time is a typical representative of microvascular proliferation. In recent years, the mechanism of microvascular proliferation under high altitude hypoxia has become a hot topic at home and abroad. Therefore, the pathways and genes of microvascular proliferation under high altitude hypoxia are reviewed in this paper.
