Research progress of T-2 toxin metabolic kinetics
10.3760/cma.j.cn231583-20201231-00353
- VernacularTitle:T-2毒素代谢动力学研究进展
- Author:
Chunhui LI
1
;
Silu CUI
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心大骨节病防治研究所 150081
- Keywords:
T-2 toxin;
HT-2 toxin;
Metabolic kinetics;
Organ damage
- From:
Chinese Journal of Endemiology
2021;40(7):599-602
- CountryChina
- Language:Chinese
-
Abstract:
As the main pollutant of food crops, T-2 toxin has toxic effects on human and animal digestive system, nervous system, reproductive development and so on. In Kashin-Beck disease related areas in China, the etiological substance of Kashin-Beck disease is the abnormal accumulation of T-2 toxin in the grain produced in the endemic area. The prevention and treatment of Kashin-Beck disease has achieved remarkable results through the comprehensive prevention and control measures, such as changing the production and life style, grain exchange, etc., but there are still pathogenic factors in the external environment of the disease area. In this paper, the metabolic kinetics of T-2 toxin is reviewed, and the physicochemical properties, distribution in the body, metabolic kinetics, biotransformation and damage of T-2 toxin and its metabolites to various organs are described, so as to provide new thinking for the study on the effects of T-2 toxin on various organs of the body.
